=== Model: grok-4.6-direct | Task: bench:gpqa_diamond | Rep: 1 ===
=== Score: 5/5 | Wall: 87.532s | Cost: $0.028722 ===
=== Pass: True | Finish: stop | In-reasoning-only: False ===

--- JUDGE ---
gpqa_diamond

--- RESPONSE ---
The statements must be evaluated against established molecular features of SARS-CoV-2. nsp14-ExoN does form an active heterodimer with nsp10 and participates in RNA proofreading, yet the resulting exonuclease activity hydrolyzes RNA (including mismatched or double-stranded substrates). The claim that the complex “prevents the breakdown of dsRNA” is therefore factually inverted and renders statement A incorrect.

Statement B recapitulates published observations that ORF3a activates caspase-8 without altering Bcl-2 levels, consistent with an extrinsic apoptotic route. Statement C restates biophysical measurements showing that frameshift efficiency scales with the number of force-induced pseudoknot conformations and that both SARS-CoV and SARS-CoV-2 signals display two such states. Statement D correctly describes the –1 programmed frameshift that generates pp1a/pp1ab from the 5'-proximal ORFs and notes the near-identity of the two viral frameshift elements.

Thus only A is inaccurate.

The answer is (A)